The aim of this review was to discuss whether measurement of free and/or bioactive IGF–I have increased the knowledge on the processes that link exercise, muscle hypertrophy, and GH/IGF–I axis. Thus, the current review will discuss (i) the different IGF–I assay methodologies and (ii) the current literature on free, bioactive, and immunoreactive (total) IGF–I in exercising subjects.
Medicine and Science in Sports and Exercise, 12/21/09
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